Bio Silymarin

Bio Silymarin2019-08-24T00:43:02+02:00

Bio-Silimarin Plus

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Bio-Silimarin Plus™ je najfiniji ekstrakt mlečnog čička koji je danas dostupan u svetu . Svaka enterično obložena kapsula osigurava potpunu apsorpciju i bioraspoloživost najmoćnijeg evropskog ekstrakta mlečnog čička. Garantovano!

Bio-Silimarin PLUS™ je poboljšana verzija jednog od najpopularnijih proizvoda koje proizvodi Aloha Medicinals, ovog puta u  gastrorezistentnoj kapsuli “Enteric Coated” (vrsta kapsule koja  se ne raspada u želucu već u tankom crevu) za još bolju apsorpciju i bioraspoloživost!
Bio-Silimarin PLUS™ – je napravljen od (suvog) ekstrakta ploda badelja. Suvi ekstrakt ploda badelja  se već dugo koristi kao podrška optimalnom zdravlju jetre.

Bio-Silimarin PLUS™ je 100%  proizveden u Americi, 100% čist i ne sadrži nikakve druge dodatke ili aditive. Ovaj proizvod sadrži sirov ekstrakt mleka čička koji se organski uzgaja i uvozi iz Nemačke.

Ovaj proizvod ne sadrži sastojke iz Kine.

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Doziranje i način upotrebe

Preporučuje se 1 kapsula  dnevno, dva meseca u kontinuitetu. U jednoj bočici ima 60 kapsula

Sastav: suvi ekstrakt ploda badelja (Silybum marianum) 500 mg, pululan (kapsula)

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ČESTO POSTAVLJANA PITANJA

Bio-Silimarin PLUS™ je poboljšana verzija jednog od najpopularnijih proizvoda koje Aloha Medicinals proizvodi. ovog puta u gastrorezistentnoj kapsuli “Enteric Coated” za još bolju apsorpciju i bioraspoloživost!

Šta je Bio-Silimarin PLUS™?

Bio-Silimarin PLUS ™ je potpuno prirodan koncentrovan i pročišćen ekstrakt semena iz biljke  mlečnog čička, “Silibum marianum”. (šareni čkalj). Sastoji se pre svega od „silimarina“, što je naziv za grupu jedinjenja mlečnog čička koja se zovu flavinoidi. Odavno je poznat i korišćen, još u drevnom Egiptu. U vreme Grka, je takođe  bio poznat, Hipokrat ga je smatrao najznačajnijim od svih biljaka.

Tokom rimskog perioda, plodovi badelja su se nosili kroz celo carstvo i bili su toliko važni da su postali jedno od glavnih predmeta trgovine. Tokom srednjeg veka u Evropi, Sikavica je poznata jos pod nazivima šareni čkalj, zmijina trava, badelj. Mleko čička se u Evropi koristi kao lek za probleme jetre već hiljadama godina. Njegova upotreba je detaljno dokumentovana u prvom veku (AD 23-79), kao biljka koja je bila odlična za zaštitu jetre. Rana hrišćanska tradicija mlečni čičak je posvetila Devici Mariji. U 19. veku Eklektici su koristili biljku za varikozne vene, menstrualne teškoće i zagušenja u jetri (kada je jetra previše puna krvi ili drugih tecnosti ) , slezini i bubrezima. Mleko čička se uzima i za povećanje proizvodnje majčinog mleka, za podsticanje izlučivanja žuči i kao lek za depresiju.

Bio-Silimarin PLUS ™ je pakovan sa jedinjenjima poznatim kao flavonoidi, koji uključuju niz  povezanih molekula, od kojih se najvažniji nazivaju silikobin, (takođe poznat i kao Silibinin, ili silikobinin), silidijanin i silihristin.  Bio-Silimarin PLUS ™ je posebno koncentrovan i prečišćen da bi se poboljšala ova specifična jedinjenja.

Bio-Silimarin PLUS ™ podržava zdravu funkciju jetre sa svojim moćnim antioksidativnim svojstvima. Silimarin može da se koristiti i kod oboljenja žučne kese i žučnih puteva, trovanja jetre različitog porekla, masne degeneracije jetre, upala jetre virusnog porekla i drugih oštećenja. Koristi se i kod dijabetesa tip 2, kod problema sa varenjem, zastoja u lučenju žuči. Silimarin se koristi kao pomoćna terapija u slučaju hemoterapije, jer sprečava oštećenja jetre i bubrega. Silimarin deluje protiv brojnih otrova jetre (kao antagonist). On povećava nivo glutationa, supstance koja detoksifikuje jetru i sprečava oštećenja pod dejstvom hemikalija, lekova, hormona. Utiče na stabilisanje membrane ćelija jetre, time sprečava ulazak toksina i stimuliše obnavljanje oštećenih ćelija. Aktivira enzime koji u jetri razgrađuju strane materije, podstiče obnovu ćelija nakon oštečenja. Važi za najbolji prirodni regenerator jetre.

Ko može da koristi Bio-Silimarin PLUS ™?

Svaka osoba koja živi modernim načinom života sa svom našom nezdravom hranom, punom konzervansa  i pesticida može uz Bio-Silimarin PLUS ™ da sebi pomogne da osigura optimalno zdravlje.

Da li je Bio-Silimarin PLUS ™ bezbedan?

Ne postoje dokumentovane kontraindikacije za Bio-Silimarin PLUS ™. To znači da nisu primećene štetne nuspojave ili opasne interakcije. Međutim, uvek je pametno da se konsultujete sa svojim lekarom ukoliko koristite  bilo kakve lekove.

Šta znamo o Silybum marianum-u?

Gujina trava (lat. Silybum marianum) je dvogodišnja zeljasta biljka iz porodice Asteraceae. Naziv je dobila jer se koristila za lečenje od ujeda otrovnih zmija. Druga imena su: sikavica, gospin trn, badelj, oslobod, šareni čkalj, divlja artičoka, itd. Poreklom je iz mediteranskih krajeva Evrope. Važi za najbolji prirodni regenerator jetre.  Izgledom podseća na čičak, ali se ove dve biljke razlikuju. Visina gujine trave je oko 2 m. Na tigrasto prošaranim listovima se nalaze bodlje koje luče otrov i otežavaju branje. Koren je vretenast i mesnat. Cvetovi su ljubičasti i bodljikavi. Plod je jajastog oblika i zaštićen je smeđom opnom.

Pošto se plod badelja koristi već više od 3.000 godina, mnogo je pisano o njegovoj sposobnosti da podrži zdravu funkciju jetre. Nacionalna biblioteka zdravlja SAD-a (www.pubmed.com) trenutno navodi skoro hiljadu nedavnih istraživačkih radova o Silimarinu. Ovi recenzirani članci su iz glavnih istraživačkih centara našeg vremena, kao što su Univerzitet Harvard, John Hopkins i Nacionalni institut za zdravlje.

Lekovitost biljke:

  • jača organizam, naročito posle operacija i teških bolesti;
  • poboljšava apetit;
  • reguliše probavu;
  • pomaže u lečenju zatvora i hemoroida;
  • ublažava tegobe koje izaziva kamen u žuči;
  • štiti i čisti jetru, a posebno se preporučuje ljudima koji konzumiraju masnu hranu i alkohol, kao i onima koji dugo piju lekove;
  • otklanja mamurluk;
  • povećava nizak krvni pritisak;
  • snižava šećer i loš holesterol;
  • uspešno suzbija alergijske reakcije;
  • pomaže u lečenju nadbubrežne žlezde;
  • ublažava upalu slepog creva;
  • pomaže u lečenju psorijaze;
  • otklanja glavobolju;
  • uspostavlja redovan menstrualni ciklus.

Silimarin deluje protiv brojnih otrova jetre (kao antagonist). Menja spoljnu građu jetrenih ćelija (hepatocita), tako da u nju više ne prodiru otrovi.Aktivira enzime koji u jetri razgrađuju strane materije, podstiče obnovu ćelija nakon oštečenja i delimično modulira imunitet.

Ovaj tekst i sajt su edukativnog karaktera, namenjeni za opšte obrazovanje i u informativne svrhe, nisu zamena za profesionalni medicinski savet, ispitivanje, dijagnozu ili lečenje.

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BIBLIOGRAFIJA:

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BioDrugs. 2001;15(7):465-89.

Silymarin: a review of its clinical properties in the management of hepatic disorders.

Wellington K1, Jarvis B.

Author information

Abstract

The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. Studies in patients with liver disease have shown that silymarin increases superoxide dismutase (SOD) activity of lymphocytes and erythrocytes, as well as the expression of SOD in lymphocytes. Silymarin has also been shown to increase patient serum levels of glutathione and glutathione peroxidase. Silybin 20 to 48 mg/kg/day has shown promise as a clinical antidote to acute Amanita (deathcap mushroom) poisoning. Primary efficacy data from 3 trials which examined the therapeutic potential of silymarin in patients with cirrhosis, and included patient survival as an end-point, demonstrated that silymarin had no significant beneficial effect on patient mortality. However, upon subanalysis, silymarin 420 mg/day had a significantly beneficial effect on patient survival rate (compared with patients receiving placebo) in 1 randomised, double-blind trial in patients with alcoholic cirrhosis. Silymarin 420 mg/day was also shown to improve indices of liver function [AST, ALT, gamma-glutamyl transferase and bilirubin] in patients with liver disease of various aetiology, including those exposed to toxic levels of toluene or xylene; however, it was largely ineffective in patients with viral hepatitis. Reports of adverse events while receiving silymarin therapy are rare. However, there have been accounts of nausea, epigastric discomfort, arthralgia, pruritus, headache and urticaria. Silymarin has also been reported to have possibly caused a mild laxative effect.

CONCLUSION:

The antioxidant properties of silymarin (a mixture of at least 4 closely related flavonolignans, 60 to 70% of which is a mixture of 2 diastereomers of silybin) have been demonstrated in vitro and in animal and human studies. However, studies evaluating relevant health outcomes associated with these properties are lacking. Although silymarin has low oral absorption, oral dosages of 420 mg/day have shown some therapeutic potential, with good tolerability, in the treatment of alcoholic cirrhosis. Moreover, silybin 20 to 48 mg/kg/day has shown promise as an antidote for acute mushroom poisoning by Amanita phalloides; however, further studies paying attention to the amount of ingested mushroom and time elapsed before administration of treatment are needed to clarify its role in this indication. Studies in patients with the early onset of liver disease may demonstrate the liver regeneration properties that silymarin is promoted as possessing.

PMID:
11520257
DOI:
10.2165/00063030-200115070-00005

[Indexed for MEDLINE]

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Curr Pharm Biotechnol. 2012 Jan;13(1):210-7.

Silymarin in the prevention and treatment of liver diseases and primary liver cancer.

Féher J1, Lengyel G.

Author information

Abstract

In chronic liver diseases caused by oxidative stress (alcoholic and non-alcoholic fatty liver diseases, drug- and chemical-induced hepatic toxicity), the antioxidant medicines such as silymarin can have beneficial effect. Liver cirrhosis, non-alcoholic fatty liver and steatohepatitis are risk factors for hepatocellular carcinoma (HCC). Insulin resistance and oxidative stress are the major pathogenetic mechanisms leading the hepatic cell injury in these patients. The silymarin exerts membrane-stabilizing and antioxidant activity, it promotes hepatocyte regeneration; furthermore it reduces the inflammatory reaction, and inhibits the fibrogenesis in the liver. These results have been established by experimental and clinical trials. According to open studies the long-term administration of silymarin significantly increased survival time of patients with alcohol induced liver cirrhosis. Based on the results of studies using methods of molecular biology, silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Furthermore, it exerts an anti-atherosclerotic effect, and suppresses tumor necrosis factor-alpha-induced protein production and mRNA expression due to adhesion molecules. The chemopreventive effect of silymarin on HCC has been established in several studies using in vitro and in vivo methods; it can exert a beneficial effect on the balance of cell survival and apoptosis by interfering cytokines. In addition to this, anti-inflammatory activity and inhibitory effect of silymarin on the development of metastases have also been detected. In some neoplastic diseases silymarin can be administered as adjuvant therapy as well.

PMID:
21466434

MEDLINE:

A New Type of Liquid Silymarin Proliposome Containing Bile Salts: Its Preparation and Improved Hepatoprotective Effects

Mei Wang, Tingting Xie, Zhanying Chang, Ling Wang, Xiangyun Xie, Yaohong Kou, Hongxia Xu, Xiaoli Gao
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Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD

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Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action

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Silymarin Prevents Restraint Stress-Induced Acute Liver Injury by Ameliorating Oxidative Stress and Reducing Inflammatory Response

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Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis

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Silymarin Ameliorates Diabetes-Induced Proangiogenic Response in Brain Endothelial Cells through a GSK-3β Inhibition-Induced Reduction of VEGF Release

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Silymarin inhibits ultraviolet radiation-induced immune suppression through DNA repair-dependent activation of dendritic cells and stimulation of effector T cells

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Effect of Silymarin (Milk Thistle) on Liver Disease in Patients With Chronic Hepatitis C Unsuccessfully Treated With Interferon Therapy: A Randomized Controlled Trial

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Impact of oral silymarin on virus- and non-virus-specific T-cells responses in chronic hepatitis C infection

Oluwasayo Adeyemo, Hiroyoshi Doi, K. Rajender Reddy, David E. Kaplan
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Silymarin Induces Insulin Resistance through an Increase of Phosphatase and Tensin Homolog in Wistar Rats

Kai-Chun Cheng, Akihiro Asakawa, Ying-Xiao Li, Hsien-Hui Chung, Haruka Amitani, Takatoshi Ueki, Juei-Tang Cheng, Akio Inui
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Prophylactic Therapy of Silymarin (Milk Thistle) on Antituberculosis Drug-Induced Liver Injury: A Meta-Analysis of Randomized Controlled Trials

Lina Tao, Xiaoyu Qu, Yue Zhang, Yanqing Song, Si-xi Zhang
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Interaction of Silymarin Flavonolignans with Organic Anion-Transporting Polypeptides

Kathleen Köck, Ying Xie, Roy L. Hawke, Nicholas H. Oberlies, Kim L. R. Brouwer
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